Overall Success Rate: 88%
Last Updated: July 11, 2024
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For many people in the nootropic world that are looking for a sharpened focus and greater levels of concentration, building your own stack is the only way to take nootropics. If you’re interested in taking a supplement that is naturally found in your body and has scientifically backed proof of its effectiveness then DMAE may just be the supplement for you. However, there have been studies that DMAE supplementation may be ineffective for some people, and in fact taking too much can give you the opposite effect that you’re looking for. So we suggest starting out at a low dose and working your way up.


DMAE stands for deanol, or 2-(dimethylamino) ethanol, which is a mouthful so we can see why they shortened it. DMAE is an amino acid that is a direct precursor and is an essential part of a series of reactions in your body that eventually form the neurotransmitter acetylcholine. If you’re interested in understanding DMAE, then you’re going to have to bear with us and learn a bit about acetylcholine first.

Acetylcholine is a neurotransmitter found throughout your body, which means it is released by nerve cells to send signals to other cells in the body. For example, acetylcholine is what the nervous system releases to activate muscles. However, inside the brain, acetylcholine functions as a type of neuromodulator, which means is it a chemical that changes how certain brain structures interpret information. Instead of transmitting information and then being absorbed or broken down as neurotransmitters are in other parts of the body, acetylcholine as a neuromodulator not only affects areas in the brain sensitive to its presence but also winds up spending a lot of time in the cerebrospinal fluid and affecting neurons in the brain for an extended period of time.

Basically, by changing the physiological processes of neurons in the brain, DMAE, which eventually converts to acetylcholine, plays an extremely important role in motivation and attention in all humans. It also protects neurons by acting as an antioxidant and increasing the permeability and fluidity of nerve membranes. Moreover, DMAE also helps promote memory formation and other cognitive processes by reducing the buildup of beta-amyloid, otherwise known as age pigmentation. This pigmentation negatively affects cognitive function and is often a reason for age-related memory loss.

Small amounts of DMAE are produced in the brain naturally, although DMAE can also be taken as a supplement. It is used by people with ADHD, Alzheimer’s disease and other forms of dementia to reduce their symptoms. Yet the new frontier of DMAE is to boost intelligence, memory production, memory retention, and mood in regular people.

However, there have been studies that show that DMAE supplementation may cause malformations of embryos in the very early stages of pregnancy. Therefore, DMAE supplements should NOT be taken by women that are pregnant or trying to get pregnant.

Manufacturer and cost:

The NOW health supplement company produces a DMAE supplement at 100 capsules of 250 mg and on Amazon one bottle was roughly $8.00 (USD). Now this was a little too cheap in our opinion, and it made us a bit curious. It turns out that DMAE is sold as DMAE bitartrate, which basically means whatever dose you see, take around 37% of it and that’s how much DMAE you’re actually getting. But the price did seem pretty consistent, since we also found DMAE sold by Source Naturals at 50 or 100 capsules of 351 mg for $4.00 (USD). You can also buy a powder form and mix it into a drink from Bulk Supplements at 100 grams for only $12.00 (USD).


If you’ve done your research and you think DMAE may just give you the relief you’re looking for, then give DMAE a try. It’s cheap and since a generally effective dose can be anywhere from 50 mg to 300 mg, you can start out small and then work your way up.

DMAE Reviewed by Brain Ehancement Advisor. Rating: 88%
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